Ene-Liis Semper (1969) studied scenography at the Estonian Academy of Arts. Since graduating in 1995, she has worked frequently in theatre and opera and received many awards for her set designs. In 2005 she and Tiit Ojasoo founded the NO99 Theatre, where she and Ojasoo are artistic directors. She has worked with Ojasoo as a co-director on several NO99 productions as well as productions for other theatres. 

In her work, Semper mixes various art forms, ranging from theatre and opera to fine art, video art, film and installation art. As well as at NO99 Theatre she has also worked at the Münchner Kammerspiele with Sebastian Nübling and Kristian Smeds and at the Malmö Opera with Dmitry Bertman. In addition to her work as a stage director and scenographer, Semper also works as a video and performance artist. She has exhibited her work around the world, including two appearances at the Venice Biennial.